Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas
DC Field | Value | Language |
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dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Sung, Hwa Jung | - |
dc.contributor.author | Choi, In Keun | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Yu, Woosung | - |
dc.contributor.author | Hwang, Hee Sang | - |
dc.contributor.author | Kim, In Sun | - |
dc.date.accessioned | 2021-09-09T16:34:05Z | - |
dc.date.available | 2021-09-09T16:34:05Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/125559 | - |
dc.description.abstract | The role of 90K and galectin-3 in cell-to-extracellular matrix adhesion and tumor metastasis has been reported, but little is known about their role in the prognosis and extranodal involvement of diffuse large B-cell lymphomas (DLBCL). Thus, we measured serum 90K concentration by enzyme-linked immunosorbent assay and tissue expression of galectin-3 by immunohistochemistry in newly diagnosed DLBCL patients. The mean serum 90K concentration was higher in DLBCL than in healthy controls (1,408.81 +/- 8 89.45 vs. 980.94 +/- 58.69 ng/ml, p = 0.036). High serum 90K (median value >= 1,249.50 ng/ml) and high galectin-3 expression (grade 3 positive staining in > 75% of cells) showed a significant association with stage III/IV, 6 2 extranodal involvements and risk of high/high-intermediate international prognostic index (p < 0.05). The complete response (CR) rate (86.9%, 20/23) in the low 90K group was higher than in the high 90K group (56.5%, 13/23). Among 14 patients with high galectin 3 expression, only 6 patients showed CR (42.9%). The time to progression and overall survival were shorter in the group with high 90K and galectin-3 expression (p<0.05). In conclusion, serum 90K and galectin-3 expression might be useful markers to indicate the extent of lymphoma involvement and prognosis in DLBCL. Copyright (C) 2009 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | MAC-2-BINDING PROTEIN | - |
dc.subject | ANTIGEN | - |
dc.title | Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Hwa Jung | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.contributor.affiliatedAuthor | Kim, Jun Suk | - |
dc.contributor.affiliatedAuthor | Kim, In Sun | - |
dc.identifier.doi | 10.1159/000193223 | - |
dc.identifier.scopusid | 2-s2.0-58249122039 | - |
dc.identifier.wosid | 000263747100004 | - |
dc.identifier.bibliographicCitation | ACTA HAEMATOLOGICA, v.120, no.4, pp.211 - 216 | - |
dc.relation.isPartOf | ACTA HAEMATOLOGICA | - |
dc.citation.title | ACTA HAEMATOLOGICA | - |
dc.citation.volume | 120 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 216 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | MAC-2-BINDING PROTEIN | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordAuthor | 90K | - |
dc.subject.keywordAuthor | Diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | Galectin-3 | - |
dc.subject.keywordAuthor | Lymphomas | - |
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