Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas
- Authors
- Kim, Seok Jin; Lee, Seung Jin; Sung, Hwa Jung; Choi, In Keun; Choi, Chul Won; Kim, Byung Soo; Kim, Jun Suk; Yu, Woosung; Hwang, Hee Sang; Kim, In Sun
- Issue Date
- 2008
- Publisher
- KARGER
- Keywords
- 90K; Diffuse large B-cell lymphoma; Galectin-3; Lymphomas
- Citation
- ACTA HAEMATOLOGICA, v.120, no.4, pp.211 - 216
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA HAEMATOLOGICA
- Volume
- 120
- Number
- 4
- Start Page
- 211
- End Page
- 216
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125559
- DOI
- 10.1159/000193223
- ISSN
- 0001-5792
- Abstract
- The role of 90K and galectin-3 in cell-to-extracellular matrix adhesion and tumor metastasis has been reported, but little is known about their role in the prognosis and extranodal involvement of diffuse large B-cell lymphomas (DLBCL). Thus, we measured serum 90K concentration by enzyme-linked immunosorbent assay and tissue expression of galectin-3 by immunohistochemistry in newly diagnosed DLBCL patients. The mean serum 90K concentration was higher in DLBCL than in healthy controls (1,408.81 +/- 8 89.45 vs. 980.94 +/- 58.69 ng/ml, p = 0.036). High serum 90K (median value >= 1,249.50 ng/ml) and high galectin-3 expression (grade 3 positive staining in > 75% of cells) showed a significant association with stage III/IV, 6 2 extranodal involvements and risk of high/high-intermediate international prognostic index (p < 0.05). The complete response (CR) rate (86.9%, 20/23) in the low 90K group was higher than in the high 90K group (56.5%, 13/23). Among 14 patients with high galectin 3 expression, only 6 patients showed CR (42.9%). The time to progression and overall survival were shorter in the group with high 90K and galectin-3 expression (p<0.05). In conclusion, serum 90K and galectin-3 expression might be useful markers to indicate the extent of lymphoma involvement and prognosis in DLBCL. Copyright (C) 2009 S. Karger AG, Basel
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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