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Impaired migration in the rostral migratory stream but spared olfactory function after the elimination of programmed cell death in Bax knock-out mice

Authors
Kim, Woon RyoungKim, YounghwaEun, BokkeePark, Ok-heeKim, HyunKim, KyungjinPark, Chang-HwanVinsant, SharonOppenheim, Ronald W.Sun, Woong
Issue Date
26-Dec-2007
Publisher
SOC NEUROSCIENCE
Keywords
neurogenesis; Bax; cell death; olfactory bulb; migration; behaviors
Citation
JOURNAL OF NEUROSCIENCE, v.27, no.52, pp 14392 - 14403
Pages
12
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE
Volume
27
Number
52
Start Page
14392
End Page
14403
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125644
DOI
10.1523/JNEUROSCI.3903-07.2007
ISSN
0270-6474
1529-2401
Abstract
Rats and mice exhibit neurogenesis of olfactory bulb (OB) interneurons throughout adulthood. To homeostatically maintain stable neuron numbers, it is necessary to continuously remove a subset of OB neurons by programmed cell death (PCD). Here we demonstrate that Bax is critical for the elimination of OB neurons by showing that Bax-KO mice exhibit greatly reduced PCD in the OB. Despite the reduction of PCD, however, proliferation of progenitors and the size of the OB were virtually unaffected in Bax-knock-out (KO) mice. However, reducing PCD by Bax deletion affected the migration of a subset of adult-produced neurons by the disruption of glial tube formation as well as by premature detachment of neuroblasts from the migratory chain. Rescued cells aberrantly remained in the subventricular zone (SVZ)-rostral migratory stream (RMS), in which they differentiated into calretinin(+) or GABA-expressing interneurons. Because of the migratory deficit, OB cell homeostasis involving new cell entry and PCD (neuronal turnover) was virtually absent in adult Bax-KO mice. Despite this, Bax-KO mice exhibited normal olfactory behaviors such as odor discrimination and olfactory memory which are thought to be influenced by adult neurogenesis. These results demonstrate that PCD is involved in the regulation of RMS migration and differentiation after OB neurogenesis, but that animals maintain normal olfactory function in the absence of PCD.
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