Metastatic medullary carcinoma of thyroid to breast; A case initially diagnosed as primary invasive lobular carcinoma - A case report -
- Authors
- Lee, Youngseok; An, Jungsuk; Kim, Chul Hwan; Yeom, Bom Woo; Choi, Jong Sang; Chae, Yang-Seok
- Issue Date
- 12월-2007
- Publisher
- KOREAN SOCIETY PATHOLOGISTS
- Keywords
- medullary carcinoma; thyroid; breast; metastasis; invasive lobular carcinoma
- Citation
- KOREAN JOURNAL OF PATHOLOGY, v.41, no.6, pp.412 - 415
- Indexed
- SCIE
- Journal Title
- KOREAN JOURNAL OF PATHOLOGY
- Volume
- 41
- Number
- 6
- Start Page
- 412
- End Page
- 415
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125669
- ISSN
- 1738-1843
- Abstract
- Metastasis to the breast from medullary carcinoma of the thyroid is extremely rare. We report a case of metastatic medullary carcinoma of the thyroid which presented as multiple breast masses with ipsilateral axillary lymphadenopathy in a 48-year-old woman. Six years ago, she underwent total thyroidectomy and neck dissection because of palpable neck masses, with a diagnosis of medullary thyroid carcinoma. Histological features of breast masses showed single-file or linear-cord arrangements, with plasmacytoid appearance, and the initial diagnosis was invasive lobular carcinoma. She underwent modified radical mastectomy. The tumor cells were diffusely positive for E-cadherin, calcitonin and thyroid transcription factor-1 (TTF-1) and were metastatic medullary carcinoma of thyroid. In the patients with a history of medullary carcinoma of the thyroid, a careful examination is necessary for a breast mass composed of solid and cord-like clusters of small round to ovoid cells with plasmacytoid appearance. Immunohistochemical staining for E-cadherin, calcitonin and TTF-1 could be helpful for differential diagnosis.
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