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Correlated expression of erbB-3 with hormone receptor expression and favorable clinical outcome in invasive ductal carcinomas of the breast

Authors
Lee, YoungseokCho, SujinSeo, Jae HongShin, Bong KyungKim, Han KyeomKim, InsunKim, Aeree
Issue Date
Dec-2007
Publisher
OXFORD UNIV PRESS INC
Keywords
HER-3; breast carcinoma; epidermal growth factor receptor family; immunohistochemistry
Citation
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.128, no.6, pp.1041 - 1049
Indexed
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume
128
Number
6
Start Page
1041
End Page
1049
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125670
DOI
10.1309/GA5VRFQFY5D0MVKD
ISSN
0002-9173
Abstract
The prognostic impact of epidermal growth factor receptor (EGFR) family members in breast carcinoma was evaluated through the analysis of 378 cases of invasive ductal carcinoma to determine the relationship between EGFR family members and clinical outcome. It was found that 13.8% of the cases were positive for erbB-3. Expression of erbB-3 was inversely correlated with EGFR and erbB-4 expression (P =.012 and P =.046). Expression of erbB-3 was correlated with positive estrogen and progesterone receptor status and inversely correlated with histologic grade. Expression of erbB-3 was correlated with longer disease-free survival (DFS; P =.028). Within the erbB-3-expressing group, there was a tendency for the coexpressing group to have shorter DFS compared with the single-expressing group. This study revealed that erbB-3 expression was associated with better prognosis. In an era of personalized targeted therapy, erbB-3 expression and its coexpressive pattern with other EGFR family members could be an important determinant for therapeutic plans for breast cancer treatment.
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