The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer
- Authors
- Kwak, Jung-Myun; Min, Byung-Wook; Lee, Ju-Han; Choi, Jong-Sang; Lee, Sun-Il; Park, Sung-Soo; Kim, Jin; Um, Jun-Won; Kim, Seon-Han; Moon, Hong-Young
- Issue Date
- 11월-2007
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- colorectal cancer; E-cadherin; liver intestine-cadherin; immunohistochemistry; overall survival; potential marker
- Citation
- DISEASES OF THE COLON & RECTUM, v.50, no.11, pp.1873 - 1880
- Indexed
- SCIE
SCOPUS
- Journal Title
- DISEASES OF THE COLON & RECTUM
- Volume
- 50
- Number
- 11
- Start Page
- 1873
- End Page
- 1880
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125683
- DOI
- 10.1007/s10350-007-9034-1
- ISSN
- 0012-3706
- Abstract
- Purpose: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. Methods: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. Results: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P < 0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. Conclusions: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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