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The effects on cognitive function and behavioral problems of topiramate compared to carbamazepine as monotherapy for children with benign rolandic epilepsy

Authors
Kang, Hoon-ChulEun, Baik-LinLee, Chang WuMoon, Han KuKim, Joon-SikKim, Dong WookLee, Joon SooChae, Kyu YoungCha, Byung HoSuh, Eun SookPark, Jung ChaeLim, KyunghwaHa, Eun HyeSong, Dong HoKim, Heung Dong
Issue Date
Sep-2007
Publisher
WILEY
Keywords
cognitive function; behavioral problems; topiramate; carbamazepine; benign rolandic epilepsy
Citation
EPILEPSIA, v.48, no.9, pp.1716 - 1723
Indexed
SCIE
SCOPUS
Journal Title
EPILEPSIA
Volume
48
Number
9
Start Page
1716
End Page
1723
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125720
DOI
10.1111/j.1528-1167.2007.01160.x
ISSN
0013-9580
Abstract
Methods: A multicenter, randomized, open-label, observer-blinded, parallel-group clinical trial was conducted. TPM was introduced at a dose of 12.5 mg/day with the minimum target dose of 50 mg/day in patients < 30 kg and 75 mg/day in patients > 30 kg over 4 weeks. CBZ was started at a dose of 10 mg/kg/day with the minimum target dose of 20 mg/kg/day over 4 weeks. Additional individual escalation was allowed up to a maximum target dose. The primary study end point was change on a neuropsychological test battery after 28 weeks of treatment. Results: Neuropsychological data were available for 88 patients (45 patients for TPM and 43 patients for CBZ). Of the cognitive variables measured, arithmetic showed significant worsening in TPM (p = 0.037). An additional test, for maze, also showed a significantly greater improvement for CBZ (p = 0.026). Of behavioral variables, no significant changes were found but the scores had a negative trend for the TPM. When 30 patients on the minimum target dose for TPM were compared to 40 patients treated with minimum target CBZ, there was no significant worsening of cognitive and behavioral effects in the TPM. Conclusion: The pattern of neuropsychometric changes with TPM seemed to be slightly worse overall than CBZ. However, outcome with the minimum target dose did not differ significantly in comparisons between the treatment groups.
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