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Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats

Authors
Kim, Min-KyungLee, Huyn-SunKim, Eun-JinWon, Nam-HeeChi, Young-MinKim, Byoung-ChulLee, Kwang-Won
Issue Date
Sep-2007
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
perilla leaf; antioxidant; hepatotoxicity; oxidative stress; tert-butyl hydroperoxide
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.45, no.9, pp.1738 - 1744
Indexed
SCIE
SCOPUS
Journal Title
FOOD AND CHEMICAL TOXICOLOGY
Volume
45
Number
9
Start Page
1738
End Page
1744
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125729
DOI
10.1016/j.fct.2007.03.009
ISSN
0278-6915
Abstract
The leaves of perilla [Perilla frutescens (L.) Britt. var. japonica (Hassk.) Hara] are often used in Asian gourmet food. The object of this study was to evaluate the protective effects of an aqueous extract of perilla leaves on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury observed in rat livers. The treatment of the hepatocytes with the perilla leaf extract (PLE) significantly reversed the t-BHP-induced cell cytotoxicity and lipid peroxidation. In addition, PLE exhibited ferric-reducing antioxidant power and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activities. The in vivo study showed that the pretreatment with PLE (1000 or 3000 mg/kg) for 5 days before a single dose of t-BHP (i.p.; 0.2 mmol/kg) significantly lowered the serum levels of aspartate aminotransferase and alanine aminotransferase, reduced the indicators of oxidative stress in the liver, such as the glutathione disulfide content and lipid peroxidation level in a dose-dependent manner, and remarkably increased the activity of hepatic gamma-glutamylcysteine synthetase. Histopathological examination of the rat livers showed that PLE reduced the incidence of liver lesions induced by t-BHP. Based on the results described above, it is suggested that PLE has the potential to protect liver against t-BHP-induced hepatic damage in rats. (c) 2007 Elsevier Ltd. All rights reserved.
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