Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels
- Authors
- Choi, S.; Na, H. S.; Kim, J.; Lee, J.; Lee, S.; Kim, D.; Park, J.; Chen, C.-C.; Campbell, K. P.; Shin, H.-S.
- Issue Date
- 7월-2007
- Publisher
- BLACKWELL PUBLISHING
- Keywords
- chemical pain; mechanical pain; neuropathic pain; spinal nerve ligation ( SNL); thermal pain; tonic inflammatory pain
- Citation
- GENES BRAIN AND BEHAVIOR, v.6, no.5, pp.425 - 431
- Indexed
- SCIE
SCOPUS
- Journal Title
- GENES BRAIN AND BEHAVIOR
- Volume
- 6
- Number
- 5
- Start Page
- 425
- End Page
- 431
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125749
- DOI
- 10.1111/j.1601-183X.2006.00268.x
- ISSN
- 1601-1848
- Abstract
- Although T-type Ca2+ channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility in mice lacking Ca(V)3.2 subtype of T-type Ca2+ channels (Ca(V)3.2(-/-)) with wild-type littermates in various behavioral models of pain to explore the roles of Ca(V)3.2 in the processing of noxious stimuli in vivo. In acute mechanical, thermal and chemical pain tests, Ca(V)3.2(-/-) mice showed decreased pain responses compared to wild-type mice. Ca(V)3.2(-/-) mice also displayed attenuated pain responses to tonic noxious stimuli such as intraperitoneal injections of irritant agents and intradermal injections of formalin. In spinal nerve ligation-induced neuropathic pain, however, behavioral responses of Ca(V)3.2(-/-) mice were not different from those of wild-type mice. The present study reveals that the Ca(V)3.2 subtype of T-type Ca2+ channels are important in the peripheral processing of noxious signals, regardless of modality, duration or affected tissue type.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.