Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome
- Authors
- Choi, K. M.; Ryu, O. H.; Lee, K. W.; Kim, H. Y.; Seo, J. A.; Kim, S. G.; Kim, N. H.; Choi, D. S.; Baik, S. H.
- Issue Date
- 2월-2007
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- C-reactive protein; interleukin-6; interleukin-10; adiponectin; metabolic syndrome
- Citation
- DIABETES RESEARCH AND CLINICAL PRACTICE, v.75, no.2, pp.235 - 240
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Volume
- 75
- Number
- 2
- Start Page
- 235
- End Page
- 240
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125820
- DOI
- 10.1016/j.diabres.2006.06.019
- ISSN
- 0168-8227
- Abstract
- We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0. 13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 mu g/ml versus 13.85 mu g/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 mu g/ml versus 0.66 mu g/ ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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