Self-Activating Therapeutic Nanoparticle: A Targeted Tumor Therapy Using Reactive Oxygen Species Self-Generation and Switch-on Drug Release
DC Field | Value | Language |
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dc.contributor.author | Kang, Rae Hyung | - |
dc.contributor.author | Kim, Yumi | - |
dc.contributor.author | Kim, Ji Hyeon | - |
dc.contributor.author | Kim, Na Hee | - |
dc.contributor.author | Ko, Hyun Min | - |
dc.contributor.author | Lee, Seung-Hyeon | - |
dc.contributor.author | Shim, Inseob | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Jang, Hyeung-Jin | - |
dc.contributor.author | Kim, Dokyoung | - |
dc.date.accessioned | 2021-11-17T06:40:17Z | - |
dc.date.available | 2021-11-17T06:40:17Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-07-07 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/127722 | - |
dc.description.abstract | One of the recent advances in nanotechnology within the medical field is the development of a nanoformulation of anticancer drugs or photosensitizers. Cancer cell-specific drug delivery and upregulation of the endogenous level of reactive oxygen species (ROS) are important in precision anticancer treatment. Within our article, we report a new therapeutic nanoformulation of cancer cell targeting using endogenous ROS self-generation without an external initiator and a switch-on drug release (ROS-induced cascade nanoparticle degradation and anticancer drug generation). We found a substantial cellular ROS generation by treating an isothiocyanate-containing chemical and functionalizing it onto the surface of porous silicon nanoparticles ( pSiNPs) that are biodegradable and ROS-responsive nanocarriers. Simultaneously, we loaded an ROS-responsive prodrug (JS-11) that could be converted to the original anticancer drug, SN-38, and conducted further surface functionalization with a cancer-targeting peptide, CGKRK. We demonstrated the feasibility as a cancer-targeting and self-activating therapeutic nanoparticle in a pancreatic cancer xenograft mouse model, and it showed a superior therapeutic efficacy through ROS-induced therapy and drug-induced cell death. The work presented is a new concept of a nanotherapeutic and provides a more feasible clinical translational pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | POROUS SILICON NANOPARTICLES | - |
dc.subject | SMALL-MOLECULE | - |
dc.subject | MOUSE MODEL | - |
dc.subject | CO-DELIVERY | - |
dc.subject | PHOTOSENSITIZERS | - |
dc.subject | PORPHYRIN | - |
dc.subject | MECHANISM | - |
dc.subject | TOXICITY | - |
dc.subject | PEPTIDE | - |
dc.subject | SIRNA | - |
dc.title | Self-Activating Therapeutic Nanoparticle: A Targeted Tumor Therapy Using Reactive Oxygen Species Self-Generation and Switch-on Drug Release | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/acsami.1c07037 | - |
dc.identifier.scopusid | 2-s2.0-85110134603 | - |
dc.identifier.wosid | 000672492800011 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.13, no.26, pp.30359 - 30372 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 13 | - |
dc.citation.number | 26 | - |
dc.citation.startPage | 30359 | - |
dc.citation.endPage | 30372 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | POROUS SILICON NANOPARTICLES | - |
dc.subject.keywordPlus | SMALL-MOLECULE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | CO-DELIVERY | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | PORPHYRIN | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | SIRNA | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | porous silicon nanoparticles | - |
dc.subject.keywordAuthor | ROS-responsive prodrug | - |
dc.subject.keywordAuthor | drug-delivery system | - |
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