Self-Activating Therapeutic Nanoparticle: A Targeted Tumor Therapy Using Reactive Oxygen Species Self-Generation and Switch-on Drug Release
- Authors
- Kang, Rae Hyung; Kim, Yumi; Kim, Ji Hyeon; Kim, Na Hee; Ko, Hyun Min; Lee, Seung-Hyeon; Shim, Inseob; Kim, Jong Seung; Jang, Hyeung-Jin; Kim, Dokyoung
- Issue Date
- 7-7월-2021
- Publisher
- AMER CHEMICAL SOC
- Keywords
- reactive oxygen species; cancer therapy; porous silicon nanoparticles; ROS-responsive prodrug; drug-delivery system
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.13, no.26, pp.30359 - 30372
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 13
- Number
- 26
- Start Page
- 30359
- End Page
- 30372
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/127722
- DOI
- 10.1021/acsami.1c07037
- ISSN
- 1944-8244
- Abstract
- One of the recent advances in nanotechnology within the medical field is the development of a nanoformulation of anticancer drugs or photosensitizers. Cancer cell-specific drug delivery and upregulation of the endogenous level of reactive oxygen species (ROS) are important in precision anticancer treatment. Within our article, we report a new therapeutic nanoformulation of cancer cell targeting using endogenous ROS self-generation without an external initiator and a switch-on drug release (ROS-induced cascade nanoparticle degradation and anticancer drug generation). We found a substantial cellular ROS generation by treating an isothiocyanate-containing chemical and functionalizing it onto the surface of porous silicon nanoparticles ( pSiNPs) that are biodegradable and ROS-responsive nanocarriers. Simultaneously, we loaded an ROS-responsive prodrug (JS-11) that could be converted to the original anticancer drug, SN-38, and conducted further surface functionalization with a cancer-targeting peptide, CGKRK. We demonstrated the feasibility as a cancer-targeting and self-activating therapeutic nanoparticle in a pancreatic cancer xenograft mouse model, and it showed a superior therapeutic efficacy through ROS-induced therapy and drug-induced cell death. The work presented is a new concept of a nanotherapeutic and provides a more feasible clinical translational pathway.
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