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Overcome the barriers of the skin: exosome therapyOvercome the barriers of the skin: exosome therapy

Other Titles
Overcome the barriers of the skin: exosome therapy
Authors
Yang, Gi HoonLee, Yoon BumKang, DongguChoi, EunjeongNam, YoonjuLee, Kyoung HoYou, Hi-JinKang, Hyo JinAn, Sang HyunJeon, Hojun
Issue Date
3-7월-2021
Publisher
SPRINGERNATURE
Keywords
Exosomes; Biomarker; Skin defects; Skin treatment
Citation
BIOMATERIALS RESEARCH, v.25, no.1, pp.230 - 242
Indexed
SCOPUS
KCI
Journal Title
BIOMATERIALS RESEARCH
Volume
25
Number
1
Start Page
230
End Page
242
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/127729
DOI
10.1186/s40824-021-00224-8
ISSN
1226-4601
Abstract
Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering.
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