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Neutralizing Antibody Responses to SARS-CoV-2 in Korean Patients Who Have Recovered from COVID-19

Authors
Kim, Yoon-JungBae, Joon-YongBae, SohyunHwang, SoyoonKwon, Ki TaeChang, Hyun-HaLee, Won KeeCui, ChunguangLee, Gee EunKim, Shin-WooPark, Man-Seong
Issue Date
7월-2021
Publisher
YONSEI UNIV COLL MEDICINE
Keywords
COVID-19; SARS-CoV-2; neutralizing antibodies; immunity; neutralization assay
Citation
YONSEI MEDICAL JOURNAL, v.62, no.7, pp.584 - 592
Indexed
SCIE
SCOPUS
KCI
Journal Title
YONSEI MEDICAL JOURNAL
Volume
62
Number
7
Start Page
584
End Page
592
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/127756
DOI
10.3349/ymj.2021.62.7.584
ISSN
0513-5796
Abstract
Purpose: Neutralizing antibodies (NAbs) have been considered effective in preventing and treating viral infections. However, until now, the duration and clinical implications of antibody-mediated nature immunity in Koreans have remained unknown. Therefore, we examined NAbs levels and clinical characteristics in recovered coronavirus disease 2019 (COVID-19) patients. Materials and Methods: Blood samples were collected from 143 adult patients who had been diagnosed with and had recovered from COVID-19 from February to March in 2020 at a tertiary-care university-affiliated hospital in Daegu, Korea. A plaque reduction neutralization test was conducted to analyze NAb titers. Individualized questionnaires were used to identify patient clinical information. Results: The median number of days from symptom onset to the blood collection date was 109.0 (104.0; 115.0). The NAb titers ranged from 10 to 2560. The median NAb titer value was 40. Of the 143 patients, 68 (47.6%) patients had NAb titers >= 80, and 31 (21.7%) patients had NAb titers >= 160. The higher the age or disease severity, the higher the NAb titer. In univariate logistic regression, statistically significant predictors of high NAb titers (>= 80) were age, myalgia, nausea or vomiting, dyspnea, and disease severity (p<0.05). Multivariable logistic regression showed that age >= 50 years (p=0.013) and moderate or higher disease severity (p<0.001) were factors associated with high NAb titers (>= 80). None of the patients had reinfection of COVID-19. Conclusion: All recovered patients were found to have NAbs regardless of the NAb titers maintained by natural immunity. Age and disease severity during COVID-19 infection were associated with high NAb titers.
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