Quercetin-3-O-glucuronide in the Ethanol Extract of Lotus Leaf (Nelumbo nucifera) Enhances Sleep Quantity and Quality in a Rodent Model via a GABAergic Mechanism
DC Field | Value | Language |
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dc.contributor.author | Kim, Singeun | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-11-20T21:41:00Z | - |
dc.date.available | 2021-11-20T21:41:00Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128162 | - |
dc.description.abstract | Current pharmacological treatments for insomnia carry several and long-term side effects. Therefore, natural products without side effects are warranted. In this study, the sleep-promoting activity of the lotus leaf (Nelumbo nucifera) extract was assessed using ICR mice and Sprague Dawley rats. A pentobarbital-induced sleep test and electroencephalogram analysis were conducted to measure sleep latency time, duration, and sleep architecture. The action mechanism of the extract was evaluated through ligand binding experiments. A high dose (300 mg/kg) of the ethanolic lotus leaf extract significantly increased sleep duration compared to the normal group (p < 0.01). Administration of low (150 mg/kg) and high doses (300 mg/kg) of the extract significantly increased sleep quality, especially the relative power of theta waves (p < 0.05), compared to the normal group. Furthermore, caffeine and lotus leaf extract administration significantly recovered caffeine-induced sleep disruption (p < 0.001), and the sleep quality was similar to that of the normal group. Additionally, ligand binding assay using [H-3]-flumazenil revealed that quercetin-3-O-glucuronide contained in the lotus leaf extract (77.27 mu g/mg of extract) enhanced sleep by binding to GABA(A) receptors. Collectively, these results indicated that the lotus leaf extract, particularly quercetin-3-O-glucuronide, exhibits sleep quantity- and quality-enhancing activity via the GABAergic pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | RAPID EYE-MOVEMENT | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | QUERCETIN | - |
dc.subject | FLAVONOIDS | - |
dc.subject | RECEPTORS | - |
dc.subject | PROMOTES | - |
dc.subject | IDENTIFICATION | - |
dc.subject | CHROMATOGRAPHY | - |
dc.subject | PROLIFERATION | - |
dc.subject | MIQUELIANIN | - |
dc.title | Quercetin-3-O-glucuronide in the Ethanol Extract of Lotus Leaf (Nelumbo nucifera) Enhances Sleep Quantity and Quality in a Rodent Model via a GABAergic Mechanism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.3390/molecules26103023 | - |
dc.identifier.scopusid | 2-s2.0-85106893245 | - |
dc.identifier.wosid | 000655061200001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.26, no.10 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | RAPID EYE-MOVEMENT | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CHROMATOGRAPHY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MIQUELIANIN | - |
dc.subject.keywordAuthor | Nelumbo nucifera | - |
dc.subject.keywordAuthor | sleep duration | - |
dc.subject.keywordAuthor | non-rapid eye movement sleep | - |
dc.subject.keywordAuthor | quercetin-3-O-glucuronide | - |
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