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Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production
- Authors
- Kim, Jun Gu; Lee, Jin Woo; Thi Phuong Linh Le; Han, Jae Sang; Cho, Yong Beom; Kwon, Haeun; Lee, Dongho; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 26-Mar-2021
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.84, no.3, pp.562 - 569
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 84
- Number
- 3
- Start Page
- 562
- End Page
- 569
- ISSN
- 0163-3864
- Abstract
- Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology