Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Bae, Eun Hui | - |
dc.contributor.author | Lim, Sang Yeob | - |
dc.contributor.author | Jung, Jin-Hyung | - |
dc.contributor.author | Oh, Tae Ryom | - |
dc.contributor.author | Choi, Hong Sang | - |
dc.contributor.author | Kim, Chang Seong | - |
dc.contributor.author | Ma, Seong Kwon | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.date.accessioned | 2021-11-23T14:40:41Z | - |
dc.date.available | 2021-11-23T14:40:41Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128485 | - |
dc.description.abstract | Obesity has become a pandemic. It is one of the strongest risk-factors of new-onset chronic kidney disease (CKD). However, the effects of obesity and abdominal obesity on the risk of developing CKD in young adults has not been elucidated. From a nationwide health screening database, we included 3,030,884 young adults aged 20-39 years without CKD during a baseline examination in 2009-2010, who could follow up during 2013-2016. Patients were stratified into five levels based on their baseline body mass index (BMI) and six levels based on their waist circumference (WC; 5-cm increments). The primary outcome was the development of CKD. During the follow up, until 2016, 5853 (0.19%) participants developed CKD. Both BMI and WC showed a U-shaped relationship with CKD risk, identifying the cut-off values as a BMI of 21 and WC of 72 cm in young adults. The obesity group (odd ratio [OR] = 1.320, 95% confidence interval [CI]: 1.247-1.397) and abdominal obesity group (male WC >= 90, female WC >= 85) (OR = 1.208, 95%CI: 1.332-1.290) showed a higher CKD risk than the non-obesity or non-abdominal obesity groups after adjusting for covariates. In the CKD risk by obesity composite, the obesity displayed by the abdominal obesity group showed the highest CKD risk (OR = 1.502, 95%CI: 1.190-1.895), especially in those under 30 years old. During subgroup analysis, the diabetes mellitus (DM) group with obesity or abdominal obesity paradoxically showed a lower CKD risk compared with the non-obesity or non-abdominal obesity group. Obesity and abdominal obesity are associated with increased risk of developing CKD in young adults but a decreased risk in young adults with diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Sang Yeob | - |
dc.identifier.doi | 10.3390/jcm10051065 | - |
dc.identifier.scopusid | 2-s2.0-85114067574 | - |
dc.identifier.wosid | 000628314900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.10, no.5, pp.1 - 13 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CIRCUMFERENCE CUTOFF POINTS | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | WAIST CIRCUMFERENCE | - |
dc.subject.keywordPlus | EPIDEMIOLOGY COLLABORATION | - |
dc.subject.keywordPlus | FASTING GLUCOSE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | abdominal obesity | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | body mass index | - |
dc.subject.keywordAuthor | waist circumference | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | korean | - |
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