Synthesis of Au-Cu Alloy Nanoparticles as Peroxidase Mimetics for H2O2 and Glucose Colorimetric Detection
- Authors
- Liu, Cun; Im, Sang Hyuk; Yu, Taekyung
- Issue Date
- 3월-2021
- Publisher
- MDPI
- Keywords
- Au& #8211; Cu alloy nanoparticles; peroxidase mimetic; H2O2 colorimetric detection
- Citation
- CATALYSTS, v.11, no.3, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- CATALYSTS
- Volume
- 11
- Number
- 3
- Start Page
- 1
- End Page
- 12
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128497
- DOI
- 10.3390/catal11030343
- ISSN
- 2073-4344
- Abstract
- The detection of hydrogen peroxide (H2O2) is essential in many research fields, including medical diagnosis, food safety, and environmental monitoring. In this context, Au-based bimetallic alloy nanomaterials have attracted increasing attention as an alternative to enzymes due to their superior catalytic activity. In this study, we report a coreduction synthesis of gold-copper (Au-Cu) alloy nanoparticles in aqueous phase. By controlling the amount of Au and Cu precursors, the Au/Cu molar ratio of the nanoparticles can be tuned from 1/0.1 to 1/2. The synthesized Au-Cu alloy nanoparticles show good peroxidase-like catalytic activity and high selectivity for the H2O2-mediated oxidation of 3,3 ',5,5 '-tetramethylbenzidine (TMB, colorless) to TMB oxide (blue). The Au-Cu nanoparticles with an Au/Cu molar ratio of 1/2 exhibit high catalytic activity in the H2O2 colorimetric detection, with a limit of detection of 0.141 mu M in the linear range of 1-10 mu M and a correlation coefficient R-2 = 0.991. Furthermore, the Au-Cu alloy nanoparticles can also efficiently detect glucose in the presence of glucose oxidase (GOx), and the detection limit is as low as 0.26 mu M.
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