Clinical implications of multidrug-resistant microorganisms and fungi isolated from patients with intra-abdominal infections in the Republic of Korea: a multicenter study
- Authors
- Yoon, Y.K.; Yang, K.-S.; Kim, J.; Moon, C.; Lee, M.S.; Hur, J.; Kim, J.Y.; Kim, S.-W.
- Issue Date
- 7월-2021
- Publisher
- Elsevier Inc.
- Keywords
- Candida; Enterococcus; Intra-abdominal infections; Mortality; Multidrug-resistance
- Citation
- Diagnostic Microbiology and Infectious Disease, v.100, no.3
- Indexed
- SCIE
SCOPUS
- Journal Title
- Diagnostic Microbiology and Infectious Disease
- Volume
- 100
- Number
- 3
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128761
- DOI
- 10.1016/j.diagmicrobio.2019.114960
- ISSN
- 0732-8893
- Abstract
- The purpose of this study was to evaluate the clinical significance of fungi and multidrug-resistant organisms (MDROs) isolated from patients with intra-abdominal infections (IAIs). This multicenter study included consecutive patients admitted for microbiologically proven IAIs at 6 university-affiliated hospitals in South Korea between 2016 and 2018. A total of 1571 patients were enrolled. Multivariable logistic regression analysis revealed that the isolation of MDROs, isolation of Candida spp., underlying renal diseases, Charlson comorbidity score ≥ 3, septic shock, failure to receive a required surgery or invasive intervention, secondary bacteremia due to IAIs, and lower body mass index were found to be independent predictors for 28-day mortality. However, the isolation of Enterococcus spp. was not identified as a significant risk factor. MDROs and Candida spp. were found in 42 (2.7%) and 395 (25.1%), patients respectively. The isolation of MDROs or Candida spp. was a surrogate marker of 28-day mortality. © 2019
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