Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Pendimethalin induces apoptosis in testicular cells via hampering ER-mitochondrial function and autophagy

Authors
Ham, J.Lim, W.Song, G.
Issue Date
1-6월-2021
Publisher
Elsevier Ltd
Keywords
Autophagy; ER stress; Herbicides; Inositol 1,4,5-triphosphate receptors; Pendimethalin
Citation
Environmental Pollution, v.278
Indexed
SCIE
SCOPUS
Journal Title
Environmental Pollution
Volume
278
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/128801
DOI
10.1016/j.envpol.2021.116835
ISSN
0269-7491
Abstract
Pendimethalin (PDM) is a dinitroaniline crop pesticide that is extensively utilized worldwide. However, the reproductive toxicity and cellular mechanisms of PDM have not been identified. Therefore, we elucidated the adverse effects of PDM on the reproductive system using mouse testicular Leydig and Sertoli cells (TM3 and TM4 cells, respectively). Our results demonstrated that PDM suppressed the viability and proliferation of TM3 and TM4 cells. Additionally, PDM induced cytosolic calcium upregulation and permeabilization of mitochondrial membrane potential in both TM3 and TM4 cells. We also verified that PDM activates the endoplasmic reticulum (ER) stress pathway and autophagy. Furthermore, we confirmed that activation of ER stress and autophagy were blocked by 2-aminoethoxydiphenyl borate (2-APB) treatment. Finally, we confirmed PDM-induced cell cycle arrest and apoptosis in TM3 and TM4 cells. Thus, we first demonstrated that PDM impedes the survival of testis cells, and further, their function. © 2021 Elsevier LtdPendimethalin might be harmful to male testicular cells by suppressing the cell cycle and stimulating ER stress and mitochondrial dysfunction. © 2021 Elsevier Ltd
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwon hwa photo

Song, Gwon hwa
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE