Association of ischemia modified albumin with mortality in qSOFA positive sepsis patients by sepsis-3 in the emergency department
DC Field | Value | Language |
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dc.contributor.author | Park, J. | - |
dc.contributor.author | Ahn, S. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Song, J. | - |
dc.contributor.author | Moon, S. | - |
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Cho, H. | - |
dc.date.accessioned | 2021-12-02T05:41:52Z | - |
dc.date.available | 2021-12-02T05:41:52Z | - |
dc.date.created | 2021-08-31 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0735-6757 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/128811 | - |
dc.description.abstract | Background: The early detection and treatment of sepsis and septic shock patients in emergency departments are critical. Ischemia modified albumin (IMA) is a biomarker produced by ischemia and oxygen free radicals which are related to the pathogenesis of sepsis-induced organ dysfunction. This study aimed to investigate whether IMA was associated with short-term mortality in quick sequential organ failure assessment (qSOFA)-positive sepsis or septic shock patients screened by the sepsis management program. Method: From September 2019 to April 2020, patients who arrived at the emergency departments with qSOFA-positive sepsis or septic shock were included in this retrospective observational study. Results: Among 124 patients analyzed, IMA was higher in the non-surviving group than in the surviving group (92.6 ± 8.1 vs. 86.8 ± 6.2 U/mL, p < 0.001). The area under the receiver operating characteristics curve was 0.703 (95% CI: 0.572–0.833, p < 0.001). The optimal IMA cutoff was 90.45 (sensitivity 60.9%, specificity 79.2%). IMA values were independently associated with 28-day mortality in the multivariate Cox proportional hazard model (adjusted hazard ratio (aHR) = 1.16, 95% CI: 1.06–1.27, p < 0.01). Conclusions: In this study, we showed that IMA in the emergency departments was associated with 28-day mortality in qSOFA-positive sepsis and septic shock patients. Further studies are needed to evaluate the clinical value of IMA as a useful biomarker in large populations and multicenter institutions. © 2021 Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W.B. Saunders | - |
dc.title | Association of ischemia modified albumin with mortality in qSOFA positive sepsis patients by sepsis-3 in the emergency department | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, H. | - |
dc.identifier.doi | 10.1016/j.ajem.2021.01.059 | - |
dc.identifier.scopusid | 2-s2.0-85100815725 | - |
dc.identifier.wosid | 000659352600014 | - |
dc.identifier.bibliographicCitation | American Journal of Emergency Medicine, v.44, pp.72 - 77 | - |
dc.relation.isPartOf | American Journal of Emergency Medicine | - |
dc.citation.title | American Journal of Emergency Medicine | - |
dc.citation.volume | 44 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 77 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Emergency Medicine | - |
dc.relation.journalWebOfScienceCategory | Emergency Medicine | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | MYOCARDIAL-ISCHEMIA | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | PROCALCITONIN | - |
dc.subject.keywordPlus | LACTATE | - |
dc.subject.keywordAuthor | Emergency department | - |
dc.subject.keywordAuthor | Ischemia modified albumin | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Sepsis | - |
dc.subject.keywordAuthor | Septic shock | - |
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