Association of ischemia modified albumin with mortality in qSOFA positive sepsis patients by sepsis-3 in the emergency department
- Authors
- Park, J.; Ahn, S.; Lee, S.; Song, J.; Moon, S.; Kim, J.; Cho, H.
- Issue Date
- 6월-2021
- Publisher
- W.B. Saunders
- Keywords
- Emergency department; Ischemia modified albumin; Mortality; Sepsis; Septic shock
- Citation
- American Journal of Emergency Medicine, v.44, pp.72 - 77
- Indexed
- SCIE
SCOPUS
- Journal Title
- American Journal of Emergency Medicine
- Volume
- 44
- Start Page
- 72
- End Page
- 77
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128811
- DOI
- 10.1016/j.ajem.2021.01.059
- ISSN
- 0735-6757
- Abstract
- Background: The early detection and treatment of sepsis and septic shock patients in emergency departments are critical. Ischemia modified albumin (IMA) is a biomarker produced by ischemia and oxygen free radicals which are related to the pathogenesis of sepsis-induced organ dysfunction. This study aimed to investigate whether IMA was associated with short-term mortality in quick sequential organ failure assessment (qSOFA)-positive sepsis or septic shock patients screened by the sepsis management program. Method: From September 2019 to April 2020, patients who arrived at the emergency departments with qSOFA-positive sepsis or septic shock were included in this retrospective observational study. Results: Among 124 patients analyzed, IMA was higher in the non-surviving group than in the surviving group (92.6 ± 8.1 vs. 86.8 ± 6.2 U/mL, p < 0.001). The area under the receiver operating characteristics curve was 0.703 (95% CI: 0.572–0.833, p < 0.001). The optimal IMA cutoff was 90.45 (sensitivity 60.9%, specificity 79.2%). IMA values were independently associated with 28-day mortality in the multivariate Cox proportional hazard model (adjusted hazard ratio (aHR) = 1.16, 95% CI: 1.06–1.27, p < 0.01). Conclusions: In this study, we showed that IMA in the emergency departments was associated with 28-day mortality in qSOFA-positive sepsis and septic shock patients. Further studies are needed to evaluate the clinical value of IMA as a useful biomarker in large populations and multicenter institutions. © 2021 Elsevier Inc.
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