Coagulation-Inspired Direct Fibrinogen Assay Using Plasmonic Nanoparticles Functionalized with Red Blood Cell Membranes
- Authors
- Kim, I.; Lee, D.; Lee, S.W.; Lee, J.H.; Lee, G.; Yoon, D.S.
- Issue Date
- 27-4월-2021
- Publisher
- American Chemical Society
- Keywords
- cardiovascular disease; coagulation-inspired; integrin αIIbβ3; localized surface plasmon resonance; red blood cell membrane
- Citation
- ACS Nano, v.15, no.4, pp.6386 - 6394
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS Nano
- Volume
- 15
- Number
- 4
- Start Page
- 6386
- End Page
- 6394
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128950
- DOI
- 10.1021/acsnano.0c08136
- ISSN
- 1936-0851
- Abstract
- The fast measurement of fibrinogen is essential in evaluating life-threatening sepsis and cardiovascular diseases. Here, we aim to utilize biomimetic plasmonic Au nanoparticles using red blood cell membranes (RBCM-AuNPs) and demonstrate nanoscale coagulation-inspired fibrinogen detection via cross-linking between RBCM-AuNPs. The proposed biomimetic RBCM-AuNPs are highly suitable for fibrinogen detection because hemagglutination, occurring in the presence of fibrinogen, induces a shift in the localized surface plasmon resonance of the NPs. Specifically, when the two ends of the fibrinogen protein are bound to receptors on separate RBCM-AuNPs, cross-linking of the RBCM-AuNPs occurs, yielding a corresponding plasmon shift within 10 min. This coagulation-inspired fibrinogen detection method, with a low sample volume, high selectivity, and high speed, could facilitate the diagnosis of sepsis and cardiovascular diseases. © 2021 American Chemical Society.
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Collections - Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
- Graduate School > Department of Bioengineering > 1. Journal Articles
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