Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | Joo, H. | - |
dc.contributor.author | Park, S.J. | - |
dc.contributor.author | Min, K.H. | - |
dc.contributor.author | Rhee, C.K. | - |
dc.date.accessioned | 2021-12-03T07:41:52Z | - |
dc.date.available | 2021-12-03T07:41:52Z | - |
dc.date.created | 2021-08-31 | - |
dc.date.issued | 2021-03-15 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129071 | - |
dc.description.abstract | Background: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD. Methods: Plasma IL-33 was measured in 62 COPD patients during their stable state. Patients were prospectively followed up for 1 year. The expression of IL-33 was measured in lung tissue obtained from 38 patients who underwent surgery. Results: The number of exacerbations was significantly higher in the high plasma IL-33 group compared with the low plasma IL-33 group. On Poisson regression analysis, high plasma IL-33 was associated with increased risk of exacerbation (incidence rate ratio = 2.166, P = 0.043). The expression of IL-33 in the lung was higher in COPD patients than in controls. The expression of IL-33 was significantly correlated with smoking pack years (R = 0.45, P < 0.01) and Forced expiratory volume in 1 s (%) (R = − 0.58, P < 0.01). Conclusion: The plasma level of IL-33 in patients with COPD was significantly associated with the risk of exacerbation in prospective follow up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function. © 2021, The Author(s). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central Ltd | - |
dc.title | Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, K.H. | - |
dc.identifier.doi | 10.1186/s12890-021-01423-8 | - |
dc.identifier.scopusid | 2-s2.0-85102427064 | - |
dc.identifier.wosid | 000629567400002 | - |
dc.identifier.bibliographicCitation | BMC Pulmonary Medicine, v.21, no.1 | - |
dc.relation.isPartOf | BMC Pulmonary Medicine | - |
dc.citation.title | BMC Pulmonary Medicine | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | Exacerbation | - |
dc.subject.keywordAuthor | Interleukin-33 | - |
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