Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease
- Authors
- Joo, H.; Park, S.J.; Min, K.H.; Rhee, C.K.
- Issue Date
- 15-3월-2021
- Publisher
- BioMed Central Ltd
- Keywords
- Chronic obstructive pulmonary disease; Exacerbation; Interleukin-33
- Citation
- BMC Pulmonary Medicine, v.21, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMC Pulmonary Medicine
- Volume
- 21
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/129071
- DOI
- 10.1186/s12890-021-01423-8
- ISSN
- 1471-2466
- Abstract
- Background: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD. Methods: Plasma IL-33 was measured in 62 COPD patients during their stable state. Patients were prospectively followed up for 1 year. The expression of IL-33 was measured in lung tissue obtained from 38 patients who underwent surgery. Results: The number of exacerbations was significantly higher in the high plasma IL-33 group compared with the low plasma IL-33 group. On Poisson regression analysis, high plasma IL-33 was associated with increased risk of exacerbation (incidence rate ratio = 2.166, P = 0.043). The expression of IL-33 in the lung was higher in COPD patients than in controls. The expression of IL-33 was significantly correlated with smoking pack years (R = 0.45, P < 0.01) and Forced expiratory volume in 1 s (%) (R = − 0.58, P < 0.01). Conclusion: The plasma level of IL-33 in patients with COPD was significantly associated with the risk of exacerbation in prospective follow up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function. © 2021, The Author(s).
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