Origami paper-based sample preconcentration using sequentially driven ion concentration polarization
- Authors
- Lee, J.; Yoo, Y.K.; Lee, D.; Kim, C.; Kim, K.H.; Lee, S.; Kwak, S.; Kang, J.Y.; Kim, H.; Yoon, D.S.; Hur, D.; Lee, J.H.
- Issue Date
- 7-3월-2021
- Publisher
- Royal Society of Chemistry
- Citation
- Lab on a Chip, v.21, no.5, pp.867 - 874
- Indexed
- SCIE
SCOPUS
- Journal Title
- Lab on a Chip
- Volume
- 21
- Number
- 5
- Start Page
- 867
- End Page
- 874
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/129090
- DOI
- 10.1039/d0lc01032d
- ISSN
- 1473-0197
- Abstract
- Ion concentration polarization (ICP) is one of the preconcentration techniques which can acquire a high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency under physiological conditions with high ionic strength and abundant biomolecules. Here, we suggested a sequentially driven ICP process, which enhanced the electrokinetic force required for preconcentration, enabling enrichment of highly ionic raw samples without increasing the electric field. We acquired a 13-fold preconcentration factor (PF) in human serum using a paper-based origami structure consisting of multiple layers for three-dimensional sequential ICP (3D seq-ICP). Moreover, we demonstrated a paper-based enzyme-linked immunosorbent assay (ELISA) by 3D seq-ICP using tau protein, showing a 6-fold increase in ELISA signals. © The Royal Society of Chemistry 2021.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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