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The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding

Authors
Ahn, JinsookWoo, Tae-GyunKang, So-miJo, InseongWoo, Jae-SungPark, Bum-JoonHa, Nam-Chul
Issue Date
2월-2021
Publisher
ELSEVIER
Keywords
Morin; Nuclear lamin A/C; Progerin; Hutchinson-Gilford progeria syndrome; Premature aging syndrome; Anti-aging
Citation
JOURNAL OF FUNCTIONAL FOODS, v.77
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
77
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/129256
DOI
10.1016/j.jff.2020.104331
ISSN
1756-4646
Abstract
Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 mu M morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.
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