Treatment of patients with chronic pruritus of unknown origin with dupilumab
DC Field | Value | Language |
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dc.contributor.author | Jeon, Jiehyun | - |
dc.contributor.author | Wang, Fang | - |
dc.contributor.author | Badic, Asima | - |
dc.contributor.author | Kim, Brian S. | - |
dc.date.accessioned | 2021-12-07T16:42:21Z | - |
dc.date.available | 2021-12-07T16:42:21Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0954-6634 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/130128 | - |
dc.description.abstract | Background Chronic pruritus of unknown origin (CPUO) is a highly debilitating disease that lacks effective treatments. This study explores a new therapeutic strategy with dupilumab. Objectives To examine whether patients with CPUO demonstrate clinical response to dupilumab. Patients and methods This is a retrospective case series examining all patients with CPUO who were treated with dupilumab from March 2017 to December 2019 at a tertiary referral clinic at Washington University School of Medicine in St. Louis, MO. Numerical rating scale (NRS) itch score changes over time were recorded and analyzed. Results Fifteen patients (67% women; mean [SD] age, 68.7 [12.6] years [range, 42-88 years]) were included in the analysis. All patients had a diagnosis of CPUO for a mean [SD] 2.6 [2.8] years. The median [IQR] pruritus NRS itch score before dupilumab injection was 8 [8-10] and the final median [IQR] NRS itch score was 1 [0-2.5]. The mean [SD] reduction in the NRS itch score was 7.0 [1.9]. Dupilumab was well tolerated with one report of mild injection site reaction that was self-resolving. Conclusion This study suggests that dupilumab may be an effective treatment for patients with CPUO and supports the design of future randomized placebo-controlled trials to prove its efficacy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Treatment of patients with chronic pruritus of unknown origin with dupilumab | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Jiehyun | - |
dc.identifier.doi | 10.1080/09546634.2021.1880542 | - |
dc.identifier.scopusid | 2-s2.0-85100744995 | - |
dc.identifier.wosid | 000616229200001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL TREATMENT, v.33, no.3, pp.1754 - 1757 | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGICAL TREATMENT | - |
dc.citation.title | JOURNAL OF DERMATOLOGICAL TREATMENT | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1754 | - |
dc.citation.endPage | 1757 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordAuthor | Chronic pruritus | - |
dc.subject.keywordAuthor | dupilumab | - |
dc.subject.keywordAuthor | itch | - |
dc.subject.keywordAuthor | numerical rating scale | - |
dc.subject.keywordAuthor | treatment | - |
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