Treatment of patients with chronic pruritus of unknown origin with dupilumab
- Authors
- Jeon, Jiehyun; Wang, Fang; Badic, Asima; Kim, Brian S.
- Issue Date
- 2022
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Chronic pruritus; dupilumab; itch; numerical rating scale; treatment
- Citation
- JOURNAL OF DERMATOLOGICAL TREATMENT, v.33, no.3, pp.1754 - 1757
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF DERMATOLOGICAL TREATMENT
- Volume
- 33
- Number
- 3
- Start Page
- 1754
- End Page
- 1757
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/130128
- DOI
- 10.1080/09546634.2021.1880542
- ISSN
- 0954-6634
- Abstract
- Background Chronic pruritus of unknown origin (CPUO) is a highly debilitating disease that lacks effective treatments. This study explores a new therapeutic strategy with dupilumab. Objectives To examine whether patients with CPUO demonstrate clinical response to dupilumab. Patients and methods This is a retrospective case series examining all patients with CPUO who were treated with dupilumab from March 2017 to December 2019 at a tertiary referral clinic at Washington University School of Medicine in St. Louis, MO. Numerical rating scale (NRS) itch score changes over time were recorded and analyzed. Results Fifteen patients (67% women; mean [SD] age, 68.7 [12.6] years [range, 42-88 years]) were included in the analysis. All patients had a diagnosis of CPUO for a mean [SD] 2.6 [2.8] years. The median [IQR] pruritus NRS itch score before dupilumab injection was 8 [8-10] and the final median [IQR] NRS itch score was 1 [0-2.5]. The mean [SD] reduction in the NRS itch score was 7.0 [1.9]. Dupilumab was well tolerated with one report of mild injection site reaction that was self-resolving. Conclusion This study suggests that dupilumab may be an effective treatment for patients with CPUO and supports the design of future randomized placebo-controlled trials to prove its efficacy.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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