Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

In-situcrystallization of sildenafil during ionic crosslinking of alginate granules

Authors
Cho, SeungvinKang, Jeong WonLee, Jonghwi
Issue Date
10월-2020
Publisher
KOREAN INSTITUTE CHEMICAL ENGINEERS
Keywords
Drug Delivery; Hydrogel; Alginate; Sildenafil; Polymer-directed Crystallization; Granule
Citation
KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.37, no.10, pp.1726 - 1731
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume
37
Number
10
Start Page
1726
End Page
1731
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/130438
DOI
10.1007/s11814-020-0580-8
ISSN
0256-1115
Abstract
Hydrogel particles containing drug crystals were investigated for the development of drug formulations with improved processability, bioavailability, and physical stability. However, crystal engineering inside hydrogel particles has been limited due to various difficulties involved in the preparation processes and their control. This study demonstrates the crosslinking of alginate granules and the simultaneous crystallization of a drug, sildenafil, inside the granules by using a simple and scalable preparation technique. The particle size of the drug crystals was successfully decreased to the submicron range while their crystallinity could be controlled by the processing parameters. Moreover, these results are shown to be due to the strong interactions between the polymer chains and the drug as well as the diffusion-limited processes of solvent, antisolvent, sildenafil, alginate, and crosslinking ions (Ca2+). This simple crystallization technique will be useful for the development of novel drug delivery systems based on hydrogels and drug crystallites.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School of Energy and Environment (KU-KIST GREEN SCHOOL) > Department of Energy and Environment > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Jeong Won photo

Kang, Jeong Won
공과대학 (화공생명공학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE