Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population
- Authors
- Kim, Tae-Joon; Yoon, Jee Eun; Park, Jung A.; Lee, Seung Ku; Chu, Min Kyung; Yang, Kwang Ik; Kim, Won-Joo; Park, Seong-Ho; Thomas, Robert J.; Shin, Chol; Yun, Chang-Ho
- Issue Date
- 2019
- Publisher
- KARGER
- Keywords
- Restless legs syndrome; Epidemiology; Cambridge-Hopkins diagnostic questionnaire
- Citation
- NEUROEPIDEMIOLOGY, v.52, no.3-4, pp.193 - 204
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROEPIDEMIOLOGY
- Volume
- 52
- Number
- 3-4
- Start Page
- 193
- End Page
- 204
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/131725
- DOI
- 10.1159/000496839
- ISSN
- 0251-5350
- Abstract
- Background: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in Korean adults is mostly 4.5-12.1%, which is higher than that reported in other Asian populations. This study aimed to diagnose RLS and exclude mimicking conditions in 2 independent samples of Korean adults, and to compare its prevalence to that from previous studies performed in Asian countries. Methods: Study populations included a (1) nationwide stratified random sample (n = 2,824; age 19-79 years) and (2) community-based cohort (n = 2,685; age 47-79 years). We applied the Cambridge-Hopkins diagnostic questionnaire to diagnose RLS and differentiate it from RLS mimics. Sleep-related symptoms, mood, and medical conditions were compared between the RLS and non-RLS groups. Prior studies of the RLS prevalence in Asia were systematically reviewed and compared to our findings. Results: The adjusted RLS prevalence was 0.4 and 1.3% in populations 1 and 2, respectively. In both populations, subjects with RLS had more depression. The prevalence of RLS mimics was 5.1 and 2.6%, in populations 1 and 2, respectively. The RLS prevalence in Asia was higher when RLS was defined by the presence of essential clinical features and lower when a differential diagnosis was additionally implemented. Conclusions: The RLS prevalence in Korean adults considering RLS mimics is comparable to that in adults from other Asian countries (<2%). The reported RLS prevalence varies depending on the diagnostic method employed. (C) 2019 S. Karger AG, Basel
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