Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
- Authors
- Jung, Hyun-Do; Lee, Hyun; Kim, Hyoun-Ee; Koh, Young-Hag; Song, Juha
- Issue Date
- 12월-2015
- Publisher
- JOURNAL OF VISUALIZED EXPERIMENTS
- Keywords
- Bioengineering; Issue 106; Porous metal scaffold; titanium; sustainable drug release; hard tissue engineering; functionally graded materials; freeze casting
- Citation
- JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, no.106
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
- Number
- 106
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/132731
- DOI
- 10.3791/53279
- ISSN
- 1940-087X
- Abstract
- Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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