Functional magnetic resonance imaging findings in Meares-Irlen syndrome: a pilot sudy
- Authors
- Kim, J.H.; Seo, H.-J.; Ha, S.-G.; Kim, S.-H.
- Issue Date
- 2015
- Keywords
- Left temporal gyrus; Magnetic resonance imaging; Meares-Irlen syndrome
- Citation
- Korean journal of ophthalmology : KJO, v.29, no.2, pp.121 - 125
- Indexed
- SCOPUS
- Journal Title
- Korean journal of ophthalmology : KJO
- Volume
- 29
- Number
- 2
- Start Page
- 121
- End Page
- 125
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/132766
- DOI
- 10.3341/kjo.2015.29.2.121
- ISSN
- 2092-9382
- Abstract
- PURPOSE: To investigate patterns of functional magnetic resonance imaging (fMRI) activation during sentence reading before and after wearing color-tinted lenses.METHODS: A total of 15 Meares-Irlen syndrome patients with a mean age of 23.4 years (range, 13 to 42 years) with no history of neurological or psychiatric disorders were scanned using a 3T MR scanner (Siemens, Tim-Trio, Germany). Each patient underwent two sessions of fMRI imaging (before and after MISViS color-tinted lens application). The fMRI paradigm included a block design of 20 seconds of rest (cross), 20 seconds of activation (sentence reading), and ten blocks (a total of 200 echo-planar image volumes) repeated for each session. Data preprocessing and analyses were performed using the SPM8 software package.RESULTS: The reading speed of patients improved more than 20% while wearing the selected lenses. When compared to the before-lens session, the after-lens session identified significant regions of activation in the left middle and superior temporal gyri (paired t-test; maximal z score, 5.38; Montreal Neurological Institute coordinate, -60 / -39 / 0; threshold at p < 0.05; corrected for multiple comparisons using family-wise error). No region of activation at the same threshold was found in the before-lens session as compared to the after-lens session.CONCLUSIONS: In the current study, we confirmed activation in the left middle and superior temporal gyri during sentence reading after wearing color-tinted lenses. These results could explain the effectiveness of color-tinted lenses in patients with Meares-Irlen syndrome.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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