The Significance of Serum Phosphate Level on Healing Index and Its Relative Effects in Skeletally Immature and Mature Patients with Hypophosphatemic Rickets
- Authors
- Song, Sang-Heon; Lee, Hanna; Jeong, Ji-Min; Cho, Woo-In; Kim, Sung Eun; Song, Hae-Ryong
- Issue Date
- 2014
- Publisher
- HINDAWI LTD
- Citation
- BIOMED RESEARCH INTERNATIONAL, v.2014
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMED RESEARCH INTERNATIONAL
- Volume
- 2014
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/133524
- DOI
- 10.1155/2014/569530
- ISSN
- 2314-6133
- Abstract
- The aim of this study was to find out the ideal cut-off level of phosphate for safe healing when deformity correction and concomitant lengthening are indicated in the two different skeletal maturity groups of patients with rickets. Thirty-nine hypophosphatemic rickets patients were selected for the study and were divided into two groups: 27 skeletally immature (group IM) and 12 skeletally mature (group M). The outcomes were evaluated with respect to the healing index (HI), laboratory findings, and complications with the mean follow-up of 5.1 years (range, 3.1-7.9). The healing index (HI) of group IM was 1.44 month/cm and HI of group M was 1.68 month/cm. The negative correlation between the level of serum phosphate and HI in group M (coefficient = -0.94) was evaluated to be less than the correlation in group IM (coefficient = -0.50), indicating that the HI is more likely to be affected by serum phosphate in group M than in group IM. Preoperative serum phosphate levels of 2.3 mg/dL and 2.6 mg/dL were analyzed to be the cut-off values of group IM and group M, respectively, in which the cut-off points divided the series into two groups having the most significantly different HI.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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