Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly
DC Field | Value | Language |
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dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Kwon, Do Young | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Park, Moon Ho | - |
dc.date.accessioned | 2021-12-28T20:40:48Z | - |
dc.date.available | 2021-12-28T20:40:48Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1340-3478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/133525 | - |
dc.description.abstract | Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (>= 1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1% men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3%) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95% confidence interval [CI]: 1.059-3.466), white blood cell count (HR=1.313; 95% CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95% CI: 1.000-1.002) and total cholesterol (HR=1.009; 95% CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPAN ATHEROSCLEROSIS SOC | - |
dc.subject | INTIMA-MEDIA THICKNESS | - |
dc.subject | MIDDLE-AGED MEN | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | SUBCLINICAL ATHEROSCLEROSIS | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | NORTHERN MANHATTAN | - |
dc.subject | RISK-FACTORS | - |
dc.subject | PLAQUE AREA | - |
dc.subject | FOLLOW-UP | - |
dc.subject | PROGRESSION | - |
dc.title | Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Man | - |
dc.contributor.affiliatedAuthor | Kwon, Do Young | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.contributor.affiliatedAuthor | Park, Moon Ho | - |
dc.identifier.doi | 10.5551/jat.18655 | - |
dc.identifier.scopusid | 2-s2.0-84901484103 | - |
dc.identifier.wosid | 000342070300007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v.21, no.5, pp.435 - 444 | - |
dc.relation.isPartOf | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.title | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 435 | - |
dc.citation.endPage | 444 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | INTIMA-MEDIA THICKNESS | - |
dc.subject.keywordPlus | MIDDLE-AGED MEN | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | SUBCLINICAL ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | NORTHERN MANHATTAN | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | PLAQUE AREA | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | Carotid arteries | - |
dc.subject.keywordAuthor | Atherosclerotic plaque | - |
dc.subject.keywordAuthor | Carotid intima-media thickness | - |
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