Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly
- Authors
- Jung, Jin-Man; Kwon, Do Young; Han, Changsu; Park, Moon Ho
- Issue Date
- 2014
- Publisher
- JAPAN ATHEROSCLEROSIS SOC
- Keywords
- Carotid arteries; Atherosclerotic plaque; Carotid intima-media thickness
- Citation
- JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v.21, no.5, pp.435 - 444
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
- Volume
- 21
- Number
- 5
- Start Page
- 435
- End Page
- 444
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/133525
- DOI
- 10.5551/jat.18655
- ISSN
- 1340-3478
- Abstract
- Aims: To investigate whether metabolic syndrome (MetS) can predict the new onset of carotid plaque or the progression of carotid intima-media thickness (C-IMT) and identify other associated factors in an elderly population without evidence of early carotid atherosclerosis. Methods: B-mode carotid ultrasonography was used to assess the presence of carotid plaque and the C-IMT at baseline and follow-up. Participants with carotid plaque or an increased C-IMT (>= 1.0 mm) at baseline were excluded from the study. The new occurrence of carotid plaque, defined as early carotid atherosclerosis and the progression of C-IMT, was evaluated. Multiple regression analyses were used to determine predictors of these findings. Results: A total of 370 participants over 60 years of age (median age=66 years, 34.1% men) were enrolled. After a median follow-up period of 25 months, 64 participants (17.3%) had newly developed carotid plaque. After adjusting for variables determined to be statistically significant in univariate analyses, a multivariable regression analysis showed that predictors of newly developed carotid plaque were metabolic syndrome (hazard ratio [HR]=1.916; 95% confidence interval [CI]: 1.059-3.466), white blood cell count (HR=1.313; 95% CI: 1.094-1.576) and vitamin B12 (HR=1.001; 95% CI: 1.000-1.002) and total cholesterol (HR=1.009; 95% CI: 1.001-1.017) levels. A multiple linear regression analysis showed that the rate of change for C-IMT tended to be associated with the development of metabolic syndrome. Conclusions: Metabolic syndrome is associated with the progression of early carotid atherosclerosis in the general population, suggesting that metabolic syndrome plays an important role in initiating the atherosclerotic process.
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