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Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl Cellulose/BioC/Bone Morphogenic Protein-2 Hybrid Materials

Authors
Song, Sang-HeonYun, Young-PilKim, Hak-JunPark, KyeongsoonKim, Sung EunSong, Hae-Ryong
Issue Date
2014
Publisher
HINDAWI LTD
Citation
BIOMED RESEARCH INTERNATIONAL, v.2014
Indexed
SCIE
SCOPUS
Journal Title
BIOMED RESEARCH INTERNATIONAL
Volume
2014
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/133526
DOI
10.1155/2014/230152
ISSN
2314-6133
Abstract
The objective of this study was to assess whether carboxymethyl cellulose-(CMC-) based hydrogel containing BioC (biphasic calcium phosphate (BCP); tricalcium phosphate (TCP) : hydroxyapatite (Hap) = 70 : 30) and bone morphogenic protein-2 (BMP-2) led to greater bone formation than CMC-based hydrogel containing BioC without BMP-2. In order to demonstrate bone formation at 4 and 8 weeks, plain radiographs, microcomputed tomography (micro-CT) evaluation, and histological studies were performed after implantation of all hybrid materials on an 8mm defect of the right tibia in rats. The plain radiographs and micro-CT analyses revealed that CMC/BioC/BMP-2 (0.5mg) led to much greater mineralization at 4 and 8 weeks than did CMC/BioC or CMC/Bio/BMP-2 (0.1mg). Likewise, bone formation and bone remodeling studies revealed that CMC/BioC/BMP-2 (0.5mg) led to a significantly greater amount of bone formation and bone remodeling at 4 and 8 weeks than did CMC/BioC or CMC/BioC/BMP-2 (0.1mg). Histological studies revealed that mineralized bone tissue was present around the whole circumference of the defect site with CMC/BioC/BMP-2 (0.5mg) but not with CMC/BioC or CMC/BioC/BMP-2 (0.1mg) at 4 and 8weeks. These results suggest that CMC/BioC/BMP-2 hybrid materials induced greater bone formation than CMC/BioC hybrid materials. Thus, CMC/BioC/BMP-2 hybrid materials may be used as an injectable substrate to regenerate bone defects.
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