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DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli
- Authors
- Lee, Byeong-Taek; Lee, Hwa-Young; Han, Changsu; Pae, Chi-Un; Tae, Woo Suk; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa; Ham, Byung-Joo
- Issue Date
- 30-9월-2011
- Publisher
- ELSEVIER
- Keywords
- Dopamine receptor D2; Polymorphism; fMRI; Striatum
- Citation
- BEHAVIOURAL BRAIN RESEARCH, v.223, no.1, pp.36 - 41
- Indexed
- SCIE
SCOPUS
- Journal Title
- BEHAVIOURAL BRAIN RESEARCH
- Volume
- 223
- Number
- 1
- Start Page
- 36
- End Page
- 41
- ISSN
- 0166-4328
- Abstract
- DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway. (C) 2011 Elsevier B.V. All rights reserved.
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