Terlipressin-induced hyponatremic seizure
- Authors
- Hyun, Jong Jin; Seo, Yeon Seok; Lee, Kwang Gyun; Keum, Bora; Yim, Hyung Joon; Jeen, Yoon Tae; Chun, Hoon Jai; Um, Soon Ho; Kim, Chang Duck; Ryu, Ho Sang
- Issue Date
- 4월-2010
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Cirrhosis; hyponatremia; seizure; terlipressin; varix
- Citation
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.45, no.4, pp.501 - 504
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Volume
- 45
- Number
- 4
- Start Page
- 501
- End Page
- 504
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/134472
- DOI
- 10.3109/00365520903477355
- ISSN
- 0036-5521
- Abstract
- Terlipressin is a splanchnic constrictor that is used to control variceal bleeding and is considered to have a very good safety profile compared to vasopressin. However, side effects such as hyponatremia and seizure, although very rare, can occur. Recently, the authors have experienced a case of hyponatremia induced by infusion of terlipressin which resulted in generalized seizure. On admission, the patient's sodium level was 141 mmol/1 but, 4 days after the initiation of terliprestin, it plummeted to 114 mmol/l, with serum osmolality also having fallen to 243 mOsm/kg. Hyponatremia could not be corrected despite correction with hypertonic saline but, after withdrawal of terlipressin, the serum sodium level showed a dramatic increase almost to the normal range the following day. Therefore, it is necessary to carefully monitor patients' electrolyte levels during the course of terlipressin therapy.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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