Mitochondria targeted fluorogenic theranostic agents for cancer therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Singh, Hardev | - |
dc.contributor.author | Sareen, Divya | - |
dc.contributor.author | George, Jiya Mary | - |
dc.contributor.author | Bhardwaj, Vineet | - |
dc.contributor.author | Rha, Saehee | - |
dc.contributor.author | Lee, Suk Joong | - |
dc.contributor.author | Sharma, Sheetal | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2022-02-10T14:40:33Z | - |
dc.date.available | 2022-02-10T14:40:33Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2022-02-01 | - |
dc.identifier.issn | 0010-8545 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135226 | - |
dc.description.abstract | Mitochondria, an eukaryotic organelle, is regarded as the most critical target since it regulates several vital functions in cell physiology. It is the hub of metabolic activity and a source of fascination due to its role in a variety of diseases like cardiovascular, cancer and neurological disorders. Because of the structural and functional discrepancies between normal and cancerous mitochondria (respiratory rate, membrane potential, genetic mutations and energy-producing pathway), mitochondria have garnered substantial attention in cancer therapy. For delivering cytotoxins exclusively to mitochondria, several synthetic strategies are used for mitochondrial dysfunction and cell apoptosis/necrosis. Covalent binding of lipophilic cations (triphenylphosphonium ion, rhodamine, peptides etc) to the molecular-based pharmacophore is the most effective process. Significant mitochondrial accumulations (>1000 folds) can be accomplished by proper selection of cell types, their mitochondrial membrane potential and targeting unit. In this review article, we address various strategies for targeting small molecule-based theranostics to cancerous mitochondria for diagnostic and potential therapeutic purposes that have been published since 2015. Particularly, conventional chemotherapeutic drugs, photosensitizers for photodynamic and photothermal treatment, drug-free agents, intra-mitochondrial aggregation agents and their combination are among the molecular-based agents discussed. (C) 2021 Published by Elsevier B.V. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.subject | AGGREGATION-INDUCED EMISSION | - |
dc.subject | PERIPHERAL BENZODIAZEPINE-RECEPTOR | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | BREAST-CANCER | - |
dc.subject | HYPOXIA | - |
dc.subject | CELLS | - |
dc.subject | PHOTOSENSITIZERS | - |
dc.subject | METABOLISM | - |
dc.subject | COMPLEXES | - |
dc.subject | DNA | - |
dc.title | Mitochondria targeted fluorogenic theranostic agents for cancer therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.ccr.2021.214283 | - |
dc.identifier.scopusid | 2-s2.0-85118572373 | - |
dc.identifier.wosid | 000719855400003 | - |
dc.identifier.bibliographicCitation | COORDINATION CHEMISTRY REVIEWS, v.452 | - |
dc.relation.isPartOf | COORDINATION CHEMISTRY REVIEWS | - |
dc.citation.title | COORDINATION CHEMISTRY REVIEWS | - |
dc.citation.volume | 452 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.subject.keywordPlus | AGGREGATION-INDUCED EMISSION | - |
dc.subject.keywordPlus | PERIPHERAL BENZODIAZEPINE-RECEPTOR | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | Theranostics | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Drug delivery | - |
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