Mitochondria targeted fluorogenic theranostic agents for cancer therapy
- Authors
- Singh, Hardev; Sareen, Divya; George, Jiya Mary; Bhardwaj, Vineet; Rha, Saehee; Lee, Suk Joong; Sharma, Sheetal; Sharma, Amit; Kim, Jong Seung
- Issue Date
- 1-2월-2022
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Mitochondria; Theranostics; Cancer; Drug delivery
- Citation
- COORDINATION CHEMISTRY REVIEWS, v.452
- Indexed
- SCIE
SCOPUS
- Journal Title
- COORDINATION CHEMISTRY REVIEWS
- Volume
- 452
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135226
- DOI
- 10.1016/j.ccr.2021.214283
- ISSN
- 0010-8545
- Abstract
- Mitochondria, an eukaryotic organelle, is regarded as the most critical target since it regulates several vital functions in cell physiology. It is the hub of metabolic activity and a source of fascination due to its role in a variety of diseases like cardiovascular, cancer and neurological disorders. Because of the structural and functional discrepancies between normal and cancerous mitochondria (respiratory rate, membrane potential, genetic mutations and energy-producing pathway), mitochondria have garnered substantial attention in cancer therapy. For delivering cytotoxins exclusively to mitochondria, several synthetic strategies are used for mitochondrial dysfunction and cell apoptosis/necrosis. Covalent binding of lipophilic cations (triphenylphosphonium ion, rhodamine, peptides etc) to the molecular-based pharmacophore is the most effective process. Significant mitochondrial accumulations (>1000 folds) can be accomplished by proper selection of cell types, their mitochondrial membrane potential and targeting unit. In this review article, we address various strategies for targeting small molecule-based theranostics to cancerous mitochondria for diagnostic and potential therapeutic purposes that have been published since 2015. Particularly, conventional chemotherapeutic drugs, photosensitizers for photodynamic and photothermal treatment, drug-free agents, intra-mitochondrial aggregation agents and their combination are among the molecular-based agents discussed. (C) 2021 Published by Elsevier B.V.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Science > Department of Chemistry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.