Current and future techniques for detecting oxytocin: Focusing on genetically-encoded GPCR sensors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dongmin | - |
dc.contributor.author | Kwon, Hyung-Bae | - |
dc.date.accessioned | 2022-02-10T21:40:32Z | - |
dc.date.available | 2022-02-10T21:40:32Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2022-01-15 | - |
dc.identifier.issn | 0165-0270 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135261 | - |
dc.description.abstract | Oxytocin is a neuropituitary hormone that is involved in a wide range of psychosocial behaviors. Despite its psychophysiological importance as a neuromodulator in the CNS, effective techniques capable of monitoring oxytocin dynamics or testing related behavioral consequences are limited. Along with an explosive advancement in synthetic biology, high-performance genetically-encoded neuromodulator sensors are being developed. Here we comprehensively review the current methodologies available for detecting oxytocin in neuroscience. Their strengths and weaknesses are discussed, and a graphical summary is plotted for better comparison of techniques. We also suggest future directions for next generation oxytocin sensor development and their working principles. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | PROTEIN-COUPLED RECEPTORS | - |
dc.subject | LUCIFERASE COMPLEMENTATION | - |
dc.subject | FLUORESCENT PROTEINS | - |
dc.subject | MICRODIALYSIS | - |
dc.subject | VASOPRESSIN | - |
dc.subject | DOPAMINE | - |
dc.subject | RELEASE | - |
dc.subject | SWITCH | - |
dc.subject | ASSAY | - |
dc.title | Current and future techniques for detecting oxytocin: Focusing on genetically-encoded GPCR sensors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongmin | - |
dc.identifier.doi | 10.1016/j.jneumeth.2021.109407 | - |
dc.identifier.scopusid | 2-s2.0-85118836238 | - |
dc.identifier.wosid | 000722687200002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE METHODS, v.366 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSCIENCE METHODS | - |
dc.citation.title | JOURNAL OF NEUROSCIENCE METHODS | - |
dc.citation.volume | 366 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | LUCIFERASE COMPLEMENTATION | - |
dc.subject.keywordPlus | FLUORESCENT PROTEINS | - |
dc.subject.keywordPlus | MICRODIALYSIS | - |
dc.subject.keywordPlus | VASOPRESSIN | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SWITCH | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordAuthor | Oxytocin | - |
dc.subject.keywordAuthor | Genetically encoded sensor | - |
dc.subject.keywordAuthor | G protein-coupled receptor | - |
dc.subject.keywordAuthor | Arrestin | - |
dc.subject.keywordAuthor | TEV protease | - |
dc.subject.keywordAuthor | Enzyme complementation | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Neuromodulator | - |
dc.subject.keywordAuthor | Neuropeptide | - |
dc.subject.keywordAuthor | Microdialysis | - |
dc.subject.keywordAuthor | Fast-scan cyclic voltammetry | - |
dc.subject.keywordAuthor | Circularly permuted fluorescent protein | - |
dc.subject.keywordAuthor | Split luciferase | - |
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