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Current and future techniques for detecting oxytocin: Focusing on genetically-encoded GPCR sensors

Authors
Lee, DongminKwon, Hyung-Bae
Issue Date
15-1월-2022
Publisher
ELSEVIER
Keywords
Oxytocin; Genetically encoded sensor; G protein-coupled receptor; Arrestin; TEV protease; Enzyme complementation; Gene expression; Neuromodulator; Neuropeptide; Microdialysis; Fast-scan cyclic voltammetry; Circularly permuted fluorescent protein; Split luciferase
Citation
JOURNAL OF NEUROSCIENCE METHODS, v.366
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE METHODS
Volume
366
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135261
DOI
10.1016/j.jneumeth.2021.109407
ISSN
0165-0270
Abstract
Oxytocin is a neuropituitary hormone that is involved in a wide range of psychosocial behaviors. Despite its psychophysiological importance as a neuromodulator in the CNS, effective techniques capable of monitoring oxytocin dynamics or testing related behavioral consequences are limited. Along with an explosive advancement in synthetic biology, high-performance genetically-encoded neuromodulator sensors are being developed. Here we comprehensively review the current methodologies available for detecting oxytocin in neuroscience. Their strengths and weaknesses are discussed, and a graphical summary is plotted for better comparison of techniques. We also suggest future directions for next generation oxytocin sensor development and their working principles.
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