Dynamic Ligand Screening by Magnetic Nanoassembly Modulates Stem Cell Differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Hyunsik | - |
dc.contributor.author | Min, Sunhong | - |
dc.contributor.author | Koo, Sagang | - |
dc.contributor.author | Lee, Yunjung | - |
dc.contributor.author | Yoon, Jinho | - |
dc.contributor.author | Jang, Woo Young | - |
dc.contributor.author | Kang, Nayeon | - |
dc.contributor.author | Thangam, Ramar | - |
dc.contributor.author | Choi, Hyojun | - |
dc.contributor.author | Jung, Hee Joon | - |
dc.contributor.author | Han, Seong-Beom | - |
dc.contributor.author | Wei, Qiang | - |
dc.contributor.author | Yu, Seung-Ho | - |
dc.contributor.author | Kim, Dong-Hwee | - |
dc.contributor.author | Paulmurugan, Ramasamy | - |
dc.contributor.author | Jeong, Woong Kyo | - |
dc.contributor.author | Lee, Ki-Bum | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Kang, Heemin | - |
dc.date.accessioned | 2022-02-11T16:40:51Z | - |
dc.date.available | 2022-02-11T16:40:51Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135357 | - |
dc.description.abstract | In native microenvironment, diverse physical barriers exist to dynamically modulate stem cell recruitment and differentiation for tissue repair. In this study, nanoassembly-based magnetic screens of various sizes are utilized, and they are elastically tethered over an RGD ligand (cell-adhesive motif)-presenting material surface to generate various nanogaps between the screens and the RGDs without modulating the RGD density. Large screens exhibiting low RGD distribution stimulate integrin clustering to facilitate focal adhesion, mechanotransduction, and differentiation of stem cells, which are not observed with small screens. Magnetic downward pulling of the large screens decreases the nanogaps, which dynamically suppress the focal adhesion, mechanotransduction, and differentiation of stem cells. Conversely, magnetic upward pulling of the small screens increases the nanogaps, which dynamically activates focal adhesion, mechanotransduction, and differentiation of stem cells. This regulation mechanism is also shown to be effective in the microenvironment in vivo. Further diversifying the geometries of the physical screens can further enable diverse modalities of multifaceted and safe unscreening of the distributed RGDs to unravel and modulate stem cell differentiation for tissue repair. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Dynamic Ligand Screening by Magnetic Nanoassembly Modulates Stem Cell Differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Seung-Ho | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Hwee | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1002/adma.202105460 | - |
dc.identifier.scopusid | 2-s2.0-85119294794 | - |
dc.identifier.wosid | 000718204400001 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, v.34, no.2 | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.citation.title | ADVANCED MATERIALS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | ORDER | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordAuthor | dynamic RGD screening | - |
dc.subject.keywordAuthor | magnetic nanoassemblies | - |
dc.subject.keywordAuthor | stem cell adhesion | - |
dc.subject.keywordAuthor | stem cell differentiation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.