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Dynamic Ligand Screening by Magnetic Nanoassembly Modulates Stem Cell Differentiation

Authors
Hong, HyunsikMin, SunhongKoo, SagangLee, YunjungYoon, JinhoJang, Woo YoungKang, NayeonThangam, RamarChoi, HyojunJung, Hee JoonHan, Seong-BeomWei, QiangYu, Seung-HoKim, Dong-HweePaulmurugan, RamasamyJeong, Woong KyoLee, Ki-BumHyeon, TaeghwanKim, DokyoonKang, Heemin
Issue Date
1월-2022
Publisher
WILEY-V C H VERLAG GMBH
Keywords
dynamic RGD screening; magnetic nanoassemblies; stem cell adhesion; stem cell differentiation
Citation
ADVANCED MATERIALS, v.34, no.2
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED MATERIALS
Volume
34
Number
2
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135357
DOI
10.1002/adma.202105460
ISSN
0935-9648
Abstract
In native microenvironment, diverse physical barriers exist to dynamically modulate stem cell recruitment and differentiation for tissue repair. In this study, nanoassembly-based magnetic screens of various sizes are utilized, and they are elastically tethered over an RGD ligand (cell-adhesive motif)-presenting material surface to generate various nanogaps between the screens and the RGDs without modulating the RGD density. Large screens exhibiting low RGD distribution stimulate integrin clustering to facilitate focal adhesion, mechanotransduction, and differentiation of stem cells, which are not observed with small screens. Magnetic downward pulling of the large screens decreases the nanogaps, which dynamically suppress the focal adhesion, mechanotransduction, and differentiation of stem cells. Conversely, magnetic upward pulling of the small screens increases the nanogaps, which dynamically activates focal adhesion, mechanotransduction, and differentiation of stem cells. This regulation mechanism is also shown to be effective in the microenvironment in vivo. Further diversifying the geometries of the physical screens can further enable diverse modalities of multifaceted and safe unscreening of the distributed RGDs to unravel and modulate stem cell differentiation for tissue repair.
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공과대학 (신소재공학부)
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