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Copper-Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering

Authors
Yoon, Hong YeolLee, DonghyunLim, Dong-KwonKoo, HeebeomKim, Kwangmeyung
Issue Date
3월-2022
Publisher
WILEY-V C H VERLAG GMBH
Keywords
click chemistry; drug delivery; hydrogels; imaging probe; metabolic glycoengineering; nanoparticles
Citation
ADVANCED MATERIALS, v.34, no.10
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED MATERIALS
Volume
34
Number
10
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135365
DOI
10.1002/adma.202107192
ISSN
0935-9648
Abstract
Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or high pressure. However, copper-free click chemistry has been shown to have favorable reaction rates and orthogonality in water, buffer solutions, and physiological conditions without toxic catalysts. Strain-promoted azide-alkyne cycloaddition and inverse electron-demand Diels-Alder reactions are representative of copper-free click chemistry. Artificial chemical reactions via click chemistry can also be used outside of the laboratory in a controllable manner on live cell surfaces, in the cytosol, and in living bodies. Consequently, copper-free click chemistry has many features that are of interest in biomedical research, and various new materials and strategies for its use have been proposed. Herein, recent remarkable trials that have used copper-free click chemistry are described, focusing on their applications in molecular imaging and therapy. The research is categorized as nanoparticles for drug delivery, imaging agents for cell tracking, and hydrogels for tissue engineering, which are rapidly advancing fields based on click chemistry. The content is based primarily on the experience with click chemistry-based biomaterials over the last 10 years.
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