Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline
DC Field | Value | Language |
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dc.contributor.author | Jung, Na-Yeon | - |
dc.contributor.author | Shin, Jeong-Hyeon | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Jang, Hyemin | - |
dc.contributor.author | Moon, Seung Hwan | - |
dc.contributor.author | Kim, Seung Joo | - |
dc.contributor.author | Kim, Yeshin | - |
dc.contributor.author | Cho, Soo Hyun | - |
dc.contributor.author | Kim, Ko Woon | - |
dc.contributor.author | Kim, Jun Pyo | - |
dc.contributor.author | Jung, Young Hee | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Kim, Eun-Joo | - |
dc.contributor.author | Na, Duk L. | - |
dc.contributor.author | Vogel, Jacob W. | - |
dc.contributor.author | Lee, Sangjin | - |
dc.contributor.author | Seong, Joon-Kyung | - |
dc.contributor.author | Seo, Sang Won | - |
dc.date.accessioned | 2022-02-12T07:41:27Z | - |
dc.date.available | 2022-02-12T07:41:27Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-12-07 | - |
dc.identifier.issn | 1664-2295 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135458 | - |
dc.description.abstract | Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (A beta) and lacune with cognitive function in patients with mild cognitive impairment (MCI).Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models.Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = -0.168/-0.175, indirect effect = -0.081/-0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = -0.037, -0.056, and 0.047, respectively).Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | ALZHEIMERS ASSOCIATION WORKGROUPS | - |
dc.subject | DIAGNOSTIC GUIDELINES | - |
dc.subject | SHAPE ABNORMALITIES | - |
dc.subject | CORTICAL THICKNESS | - |
dc.subject | NATIONAL INSTITUTE | - |
dc.subject | DISEASE | - |
dc.subject | IMPAIRMENT | - |
dc.subject | BETA | - |
dc.subject | DEMENTIA | - |
dc.subject | ATROPHY | - |
dc.title | Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Joon-Kyung | - |
dc.identifier.doi | 10.3389/fneur.2021.762251 | - |
dc.identifier.scopusid | 2-s2.0-85121742712 | - |
dc.identifier.wosid | 000742572900001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, v.12 | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.citation.title | FRONTIERS IN NEUROLOGY | - |
dc.citation.volume | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ALZHEIMERS ASSOCIATION WORKGROUPS | - |
dc.subject.keywordPlus | DIAGNOSTIC GUIDELINES | - |
dc.subject.keywordPlus | SHAPE ABNORMALITIES | - |
dc.subject.keywordPlus | CORTICAL THICKNESS | - |
dc.subject.keywordPlus | NATIONAL INSTITUTE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordAuthor | mediation | - |
dc.subject.keywordAuthor | subcortical structure | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | lacune | - |
dc.subject.keywordAuthor | cognition | - |
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