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Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Authors
Jung, Na-YeonShin, Jeong-HyeonKim, Hee JinJang, HyeminMoon, Seung HwanKim, Seung JooKim, YeshinCho, Soo HyunKim, Ko WoonKim, Jun PyoJung, Young HeeKim, Sung TaeKim, Eun-JooNa, Duk L.Vogel, Jacob W.Lee, SangjinSeong, Joon-KyungSeo, Sang Won
Issue Date
7-12월-2021
Publisher
FRONTIERS MEDIA SA
Keywords
mediation; subcortical structure; amyloid; lacune; cognition
Citation
FRONTIERS IN NEUROLOGY, v.12
Indexed
SCIE
SCOPUS
Journal Title
FRONTIERS IN NEUROLOGY
Volume
12
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135458
DOI
10.3389/fneur.2021.762251
ISSN
1664-2295
Abstract
Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (A beta) and lacune with cognitive function in patients with mild cognitive impairment (MCI).Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models.Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = -0.168/-0.175, indirect effect = -0.081/-0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = -0.037, -0.056, and 0.047, respectively).Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.
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