Concurrent enhancement of CO2 fixation and productivities of omega-3 fatty acids and astaxanthin in Haematococcus pluvialis culture via calcium-mediated homeoviscous adaptation and biomineralization
- Authors
- Yu, Byung Sun; Sung, Young Joon; Il Choi, Hong; Sirohi, Ranjna; Sim, Sang Jun
- Issue Date
- 11월-2021
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Astaxanthin; Biomineralization; Haematococcus pluvialis; Omega-3 fatty acids
- Citation
- BIORESOURCE TECHNOLOGY, v.340
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIORESOURCE TECHNOLOGY
- Volume
- 340
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135895
- DOI
- 10.1016/j.biortech.2021.125720
- ISSN
- 0960-8524
- Abstract
- Haematococcus pluvialis has attracted interest as a bio-platform for producing omega-3 fatty acids (omega-3 FA) and astaxanthin that have a great potential as anti-inflammatory drugs. This study aimed to concurrently enhance the CO2 fixation and the productivities of omega-3 FA and astaxanthin, which have been difficult to achieve because of the dissimilar culture methods for each goal, via calcium-mediated homeoviscous adaptation and biomineralization. As a result of 3 mM of Ca2+ addition, omega-3 FA content was improved by 31% due to Ca2+-induced homeoviscous adaptation. Biomineralization was promoted by the extracellular carbonic anhydrase, which resulted in 46.3% improvement in CO2 fixation. CaCO3 from the biomineralization was beneficially re-used in the H. pluvialis culture and triggered 178- and 522-fold increased biomass productivity and astaxanthin content, respectively, thanks to its anisotropic nature. The Ca2+-based productivity enhancement strategy was applied to large-scale culture which resulted improvement in overall bioprocess performance.
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Collections - College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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