beta-Defensin 2, an Antimicrobial Peptide, as a Novel Biomarker for Ulcerative Interstitial Cystitis; Can beta-Defensin 2 Suspect the Dysbiosis of Urine Microbiota?<br>
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Wook | - |
dc.contributor.author | Kim, Si Hyun | - |
dc.contributor.author | Lee, Kwang Woo | - |
dc.contributor.author | Kim, Woong Bin | - |
dc.contributor.author | Choi, Hae Woong | - |
dc.contributor.author | Moon, Ji Eun | - |
dc.contributor.author | Moon, Ahrim | - |
dc.contributor.author | Kim, Young Ho | - |
dc.date.accessioned | 2022-02-16T04:42:24Z | - |
dc.date.available | 2022-02-16T04:42:24Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135943 | - |
dc.description.abstract | As urine is not sterile, inflammatory reactions caused by dysbiosis of the urinary microbiota may induce interstitial cystitis. A study was conducted to determine whether beta-defensin 2 (BD-2), a specific antimicrobial peptide in the bladder, could be used as a novel diagnostic marker for ulcerative interstitial cystitis (IC). Urine samples from three female groups were examined: healthy controls (n = 34, Control group), non-Hunner type IC (n = 40, NHIC group), and Hunner type IC (n = 68, HIC group). Urine samples were collected via a transurethral catheter and assayed for BD-2 levels using enzyme linked immunosorbent assay. Under general or regional anesthesia, cystoscopy with diagnostic and therapeutic hydrodistension was performed in NHIC and HIC groups patients. These patients underwent a biopsy of the bladders. Based on the urinary specimens from 142 patients, BD-2 expression was found to be 18-fold higher in patients with Hunner type IC than in patients with non-Hunner type IC. The enhanced secretion of BD-2 exhibited a strong correlation with increased mast cell counts associated with bladder IC pathology. Enhanced urinary secretion of the antimicrobial peptide BD-2 from Hunner type IC patients associated with clinical phenotypes and demonstrated relatively robust levels to be used as a potential biomarker. Moreover, the increased urinary level of BD-2 may suggest a new possibility of biomarkers caused by dysbiosis of the urinary microbiota in ulcerative IC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MAST-CELLS | - |
dc.subject | STERILE | - |
dc.subject | SHIFT | - |
dc.title | beta-Defensin 2, an Antimicrobial Peptide, as a Novel Biomarker for Ulcerative Interstitial Cystitis; Can beta-Defensin 2 Suspect the Dysbiosis of Urine Microbiota?<br> | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Hae Woong | - |
dc.identifier.doi | 10.3390/diagnostics11112082 | - |
dc.identifier.scopusid | 2-s2.0-85119587154 | - |
dc.identifier.wosid | 000724492800001 | - |
dc.identifier.bibliographicCitation | DIAGNOSTICS, v.11, no.11 | - |
dc.relation.isPartOf | DIAGNOSTICS | - |
dc.citation.title | DIAGNOSTICS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | STERILE | - |
dc.subject.keywordPlus | SHIFT | - |
dc.subject.keywordAuthor | interstitial cystitis | - |
dc.subject.keywordAuthor | biomarkers | - |
dc.subject.keywordAuthor | urine specimen collection | - |
dc.subject.keywordAuthor | antimicrobial peptide | - |
dc.subject.keywordAuthor | beta-defensins | - |
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